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Ferroptosis has been widely observed in small-molecule treated cells in vitro, and was implicated in various pathological conditions including neurodegeneration, ischemia/reperfusion-induced kidney, heart and liver injury, and stroke 2

doi: 10.3389/fnut.2018.00080 167 HooperLVWongMHThelinAHanssonLFalkPGGordonJI

We were also unable to assess dose-dependent effects due to dose escalation and inconsistent reporting across the included studies, and a network meta-analysis was beyond the scope of our review