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Its anti-inflammatory effects on NFkB a key mediator of age-related inflammatory disease and its DNA repair activity suggest potential relevance in broader regenerative medicine, though most of these applications remain under investigation

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By supplementing NAD + precursors or activating the Sirtuin 1 (SIRT1)/AMPK pathway, mitochondrial biogenesis and antioxidant capacity can be synergistically enhanced, correcting immune-metabolic imbalance in both directions and providing an additional molecular target for IBD intervention [458, 459]

Though unable to provide atomic-level detail offered by X-ray crystallography or NMR, these methods were the first to reveal that many functional proteins exist as a dynamic ensemble of conformations rather than a single fixed structure