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In plants, stress conditions can deplete free GSH which is partially due to its utilization in GSH-dependent detoxification of RCS as well as of methylglyoxal and glyoxal

Individuals at higher risk include older adults with reduced stomach acid production, people with gastrointestinal conditions affecting absorption, strict vegans, and those taking medications like metformin or proton pump inhibitors

However, no structural information could be obtained for the non-canonical amino acids as these residues were either replaced or could not be 13 C, 15 N-labelled in the synthetic teixobactin and were thus inaccessible by ssNMR

Casida J, Quistad G., (2004)

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