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Despite the role of gut microbiota in the modulation of dopamine and norepinephrine remains to be fully understood, germ-free (GF) animal models have shown that there is a noteworthy alteration of these neurotransmitters in the gut as well as in the brain, which could have important consequences in the behavior [178]

Alagoz G, Celiker U, Ilhan N, Yekeler H, Demir T, Celiker H

It is possible that these differences are explained by cell typespecific differences, or the ability of p21 to regulate redox homeostasis via alternative means in some contexts (Chen et al, 2009)

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Beyond nanoformulations, other innovative delivery strategies have been investigated to further enhance curcumins pharmacokinetic and pharmacodynamic properties