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Zhu B, Wang K, Liang Z, Zhu Z, Yang J (2022) Transcriptome analysis of glutathione response: RNA-Seq provides insights into balance between antioxidant response and glucosinolate metabolism

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GPX4, a downstream target of GSH action, functions as a unique intracellular antioxidant enzyme acting on membrane lipid repair, which is able to directly reduce peroxidized phospholipids produced in cell membranes (88,89), and it converts toxic lipid ROS into non-toxic lipid alcohols with the aid of GSH, which thereby reduces the level of oxidative damage to cells (90)