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Bioluminescence was monitored at 28C on a Packard TopCount NXT scintillation counter (Perkin Elmer)

Current strategies aimed at restoring FAO primarily involve compounds that activate the PPAR, PGC-1, and AMPK signaling pathways ( Dysregulation of the mTOR and AMPK signaling pathways has been implicated in the metabolic reprogramming of TECs during AKI

In adipose tissue, 5-LOX interruption leads to a remarkable insulin-sensitizing effect by increasing PPAR expression, IRS1 activity, and adiponectin level that is accompanied by reduced inflammatory response

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Early detection and management of CIC are crucial for minimizing the associated morbidity and mortality