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Frentzas S, Simoneau E, Bridgeman VL, Vermeulen PB, Foo S, et al

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found patterning signals like Shh expression were downregulated over time while expression of synthetic genes like TGF- and insulin growth factor (IGF) were upregulated in the same developmental window, providing insights into gene families required for patterning, ECM synthesis, and maintenance of the NP