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A number of factors limit their use in therapeutics, including rapid degradation through nucleases, rapid clearance via renal filtration, and a lack of chemical diversity among others (90)

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A study on sumatriptan found higher posterior deposition for powder, but similar nasopharyngeal clearance rates for both forms [38]

However, the natural decomposition is slow and thus the resultant low release of nutrients will limit the agronomic benefits of buried animal by-products and carcasses as a nutrient source for crops or soil improvement