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Pharmacologists call this a flattening dose-response curve, and it carries enormous practical implications

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Moreover, it is found that Sox2 can suppress Sat1 expression at the transcriptional level

1,8-diMQ and 5-amino-1MQ showed little inhibition of COMT at maximal tested concentrations of 200 M (20% inhibition) and 600 M (10% inhibition), respectively, although no clear trend of concentration-dependent inhibition was observed