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At the same time, they may need more of it because the body is dealing with more oxidative stress, more inflammation, and more disease pressure

Riboflavin also plays a role in thyroxine metabolism, and its deficiency may contribute to mental illness, because riboflavin activates vitamin B6, leading to lower thyroxine levels, reduced hypothalamic serotonin synthesis, and decreased levels of S-adenosylmethionine (SAMe), because of disrupting the folate-methylation pathways involved in SAMe synthesis, all of which are associated with antidepressant effects, consequently, low levels of these compounds may cause depression ( Figure 4 ) (48, 49)

Absorption of oral glutathione can be affected by stomach acid or enzymes in the duodenum, which can break glutathione into its amino acid components

Zhang et al., 2022

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