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Exploration 2 , 20210217 (2022)

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Consistently, in the GLS-deficient mouse tumor model, the increased concentration of glutamine in the TME due to restricted glutamine utilization by tumor cells leads to elevated levels of glutamine available to tumor-infiltrating T lymphocytes, thereby enhancing its anti-tumor activity [17]

Most homocysteine is remethylated to methionine using methyl groups from the folate cycle or donated from trimethylglycine (also called betaine)

Comparative quantitative lipidomic analyses of patient-matched initial versus recurrent GBM (rGBM) reveal decreased levels of ceramides, glycerolipids, sphingolipids, and triacylglycerols, alongside increased levels of glycerophosphoglycerols