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Additionally, the decomposed calixarene molecules themselves possess intrinsic bio-activation to modulate inflammatory responses, achieving a multistage therapeutic approach that transitions from targeting to release and finally to treatment

Rapid eye movement (REM) sleep behavior patterns disorder and severe anti-psychotic sensitivity are suggestive clinical features of Lewy body dementia patients, who also exhibit main clinical features such as fluctuating cognition, visible hallucinations, and one or more Parkinson's symptoms that appear after the occurrence of cognitive loss) and suggestive biomarkers (poor uptake of iodine-123-meta-iodobenzylguanidine) (123-MIBG), decreased dopamine transporter uptake in the basal ganglia on single photon emission computed tomography (SPECT) or positron emission tomography (PET), and rapid eye movement (REM) sleep without atonia on polysomnography (PSG) [103,104,105,106]

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