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In silico studies show that curcumin, when combined with chemotherapy drugs, exhibit strong interactions with target proteins, with curcumin achieving the highest interaction scores with marker proteins, and curcumin derivatives fitting well in the active site of target proteins, suggesting their potential as effective anticancer agents for breast cancer [267, 268]

Multiple genome-wide association studies (GWAS) have identified key susceptibility genes and elucidated their mechanisms of action

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We probed this potential link by integrating transcriptomic and metabolomic analysis on murine tumors combined with functional studies on primary cell cultures derived from the two models (Fig

4 (2019): 856870.e7, 10.1016/j.cmet.2018.12.023