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further evidence that this is a benign disorder

Malo MS, Alam SN, Mostafa G, Zeller SJ, Johnson PV, Mohammad N, Chen KT, Moss AK, Ramasamy S, Faruqui A, Hodin S, Malo PS, Ebrahimi F, Biswas B, Narisawa S, Millan JL, Warren HS, Kaplan JB, Kitts CL, Hohmann EL, Hodin RA (2010) Intestinal alkaline phosphatase preserves the normal homeostasis of gut microbiota

As such, interventions aimed to reduce SOD1 G93A expression and/or SOD1 G93A protein accumulation are most likely to achieve large rescuing effects in this model, whereas interventions that do not directly target the SOD1 G93A mechanisms are less likely to achieve success in retarding motor neuron disease of this model 23,24,25

PML has traditionally been treated with all-trans retinoic acid (ATRA) paired with anthracycline-based chemotherapy (typically danorubicin) [2]

Thioctic acid has been shown to be effective in a wide range of clinical conditions including diabetes and its complications, heart diseases, cancer, heavy metal intoxication, HIV infection, cataract, liver diseases, neurodegenerative diseases and age-related pathologies [39]