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Moreover, Nrf2a key regulator of iron homeostasisis robustly activated by BL (Yao et al., 2020a,b), leading to increased production of NAD(P)H-dependent enzymes such as NQO1, suppression of NF-B signaling, and reduction of both -Syn aggregation and oxidative stressmediated neuroinflammatory damage (Lastres-Becker et al., 2016

The increased levels of lipid peroxide and ROS in FRDA neurons and the decrease in GSH content increase the sensitivity to oxidants, suggesting that FRDA may be closely related to ferroptosis 69

Not for Injection: The nasal spray is strictly for intranasal use and should never be injected

Pairing a local repair signal with a systemic one is the rationale for the stack

Section S2 of the prohibited list covers peptide hormones, growth factors, related substances, and mimetics