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A., Hakkinen, K., & Volek, J

We observe a hydrophobic extracellular gate directly above the substrate-binding site, similar to that seen in OCT1, where residues of gating helices TM1 and TM7 pack together in both the occluded and inward conformations (e.g

To address this, we analyzed these metabolites in isolated cerebral vessels and in the brain parenchyma over a range of ages in the APOE-TR mouse model