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GTT, ITT, GSIS and circulating -hydroxybutyrate Glucose and -hydroxybutyrate (ketones) were measured by handheld glucometer (Contour Next EZ, Bayer HealthCare) and handheld ketometer (GK+, Keto-Mojo), respectively, after using a lancet to draw a drop of blood from the tip of the tail

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The normal range of PT is 9 to 11 seconds

In parallel, advances in peptide chemistry and structural biology have enabled the design of aggregation inhibitors, receptor-selective neuropeptide analogues, and cell-penetrating or brain-targeted peptide conjugates that modulate key pathways, including proteostasis, insulin and incretin signaling, neurotrophic support, and microglial activation

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