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staggered titration Cycle driver GI tolerance sets the pace Tirzepatide Loading 2.5 5 7.5 10 12.5 mg (every 4 weeks) Frequency Once weekly Maintenance 15 mg weekly Route SubQ Cagrilintide Loading Start Week 9: 0.25 0.5 1.0 1.7 mg Frequency Once weekly Maintenance 2.4 mg weekly Route SubQ Weekly Schedule Example (Maintenance Phase) Monday Tirzepatide 15 mg (one site) + Cagrilintide 2.4 mg (different site) Tuesday No injections Wednesday No injections Thursday No injections Friday No injections Saturday No injections Sunday No injections Both compounds are once weekly

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In fact, this regimen was already tested in metastatic breast cancer with encouraging results (Falanga et al., 1998)

compounded formulations with enhanced penetration vehicles offer an alternative for patients who cannot tolerate or prefer to avoid systemic antifungals