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Under normal conditions, NRF2 is bound to Keap1 (Kelch-like ECH-associated protein 1) and subsequently degraded

In: Karakochuk CD, Zimmermann MB, Moretti D, Kraemer K, eds

Improved brain penetration and antitumor efficacy of temozolomide by inhibition of ABCB1 and ABCG2

In modeling, three templates such as 2F8A:A ( GPX1, GPX3, GPX6 , and GPX7 ), 2V1M:A ( GPX2 and GPX5 ), and 2P5Q:A ( GPX4 and GPX8 ) were used to maximize the alignment coverage, percentage identity and confidence for submitted sequences