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Higher doses increase side effect risk without proportional benefit increases

96372: For therapeutic/diagnostic drugs (e.g., [Ketorolac] for pain)

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medRxiv 2026, IQVIA PharMetrics cohort (n=20,504 non-diabetic weight-loss users), incident allodynia 35 vs 15 per 1,000 person-years against bupropion-naltrexone, adjusted HR 2.15 (95% CI 1.572.96)