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In IMR-5/75 cells, MYCN downregulation still maintains amplification-level expression, which may explain the modest effect on treatment sensitivity

In aged mice treated for 8 weeks at 10 mg/kg daily, sedentary mice showed approximately 40% greater grip strength than controls, and when combined with exercise, grip strength improved by approximately 60%

The only side effect Ive experienced is a bit of constipation, but I manage that easily with over-the-counter senna