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At the genus level, Oscillospira and Bifidobacterium increased, but unclassified Clostridiaceae, Prevotella, and Akkermansia decreased

Metabolic abnormalities such as the Warburg effect, which is characterized by excessive glucose uptake and lactate generation, are frequently seen in cancer cells (Hu et al., 2022)

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While there is no evidence of common structural or functional brain alterations in PAIS, probably due to its heterogeneous origin and lack of conceptualization, ME/CFS has been extensively studied with MRI (magnetic resonance imaging), as recently reviewed by Nelson et al

Another study pointed out that pretreatment with 100 mg/kg NAC eliminated paclitaxel-induced allodynia in the CIPN mouse model, while in RAW264.7 cells, 50 mM NAC completely blocked the paclitaxel-induced release of high mobility group box 1 (HMGB1) and upregulation of CREB-binding protein (CBP) and p300/CBP-associated factor (PCAF) [63]