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Specifically, prolyl-4-hydroxylases (PHDs) catalyze the oxidation of proline residues at positions 402 and 564 on HIF-1

Collectively, increased levels of DNA damage may have important consequences in vivo

One commenter expressed their belief that applying the policy retroactively is consistent with section 1871(e)(1)(A)(ii) of the Act that provides statutory authority to retroactively apply a substantive change in regulation when failure to do so would be contrary to the public interest