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Some children with autism have issues in their folate metabolism, particularly a problem getting folate into the brain a phenomenon known as cerebral folate deficiency

The identified metabolite, ICA, plays a crucial role in suppressing Treg differentiation and enhancing the function of CD8+ T cells

In turn, lactate-induced H3K18la upregulates SRSF10 expression in macrophages, eventually forming the SRSF10/glycolysis/H3K18la positive feedback loop with tumor cells and promoting M2 macrophage polarization in the tumor microenvironment (TME)

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Additional preclinical evidence further supports edaravones potential in oral mucositis