Major barriers to the clinical use of gene therapy, however, include transfection efficiency, the creation of long-term effects, the difficulty of controlling cell proliferation, ectopic transfection, disease transmission, patient-specific dose responses, immune reactions against viral proteins, possible side effects, and ethical issues [87, 88]
C.ShaoL.YoungL
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N.FendiF.MosriulaM.BakriM.KaryawatiK.et al
Another innovative biophysical therapeutic agent, S-1226, employs carbon dioxide (CO 2 )-rich air in combination with aerosolized perfluorocarbons (PFOB) to promote airway dilation, enhance mucus clearance, and improve blood oxygenation
