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Yudin D, Hanz S, Yoo S, Iavnilovitch E, Willis D, Gradus T, et al

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The gradient was started at 50% (v/v) acetonitrile, which was increased to 100% acetonitrile in 10 min

Herein, we describe a novel approach not only for the rapid and high-yielding chemical generation of bispecific antibodies from native antibody fragments, but also for the site-specific dual functionalization of the resulting bioconjugates