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PDHC deficiency is commonly characterized by lactic acidosis, neurologic and neuromuscular degeneration, and death during childhood

PDN@AGL inhibits ferroptosis by reducing ROS levels and lipid peroxidation, and the regulation of the ATF3/SLC7A11 pathway is believed to play a crucial role in this process

Confocal laser endomicroscopy in the evaluation of inflammatory Bowel disease

1) that is one of the most applied worldwide, introduced on the market in the 1940s to control broad-leaved weeds such as wheat, soybean, corn, and other crops 11,12

For the research context it expanded the perspective from pure longevity to specific clinical indications , especially neurodegenerative diseases, where mitochondrial dysfunction and NAD+ deficit play a central role