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Description

PreissHandler and de novo do not occur within the mitochondria, based on the nuclear or cytosolic localization of QPRT, NAPRT, and NADS 48

Such a CoQ-free pool can be applied by enzymes linking the MRC to other pathways, like the fatty acid -oxidation and amino acid catabolism, pyrimidine de novo biosynthesis, proline, arginine, and glyoxylate metabolism, glycine metabolism, and sulfide oxidation metabolism that some of them are attached to metabolic pathways in other compartments (Pradhan et al., 2021)