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On the other hand, during such exhaustive exercises, the threshold for maintaining architectural or stoichiometric strength of the skeletal muscle is frequently exceeded, resulting in muscle damage, accompanied by elevation of various serum biomarkers, including creatine kinase (CK), aspartate aminotransferase (AST), alanine aminotransferase and lactate dehydrogenase (LDH), which are released through the affected muscle cell membrane 14,15,16

Inflammatory cytokines, such as IL-6, may also exacerbate insulin and leptin resistance through SOCS3 [124, 227], while promoting mitochondrial dysfunction [228]an issue commonly observed in critically ill patients

Phytother Res 36:23002323

Exceeding this dose can lead to serious problems due to a metabolite of the drug being toxic to the liver

Grab D, Lanners H, Williams W, Bucala R