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Exogenous hydrogen sulfide mitigates NLRP3 inflammasome-mediated inflammation through promoting autophagy via the AMPK-mTOR pathway

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Engel 4 , (1)Ucm Digestive Diseases, Virgen Del Rocio University Hospital, Instituto De Biomedicina De Sevilla, Ciberehd, University of Seville, Sevilla, Spain, (2)Texas Liver Institute, University of Texas Health San Antonio, San Antonio, TX, USA, (3)Merck & Co., Inc., Rahway, NJ, USA, (4)Global Clinical Development, Merck & Co., Inc., Rahway, NJ, USA Background: Hispanic (HISP) patients have been reported to have a higher prevalence and severity of nonalcoholic steatohepatitis (NASH) compared to other ethnicities in the USA