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J Biol Chem 298:102211

D.ZhangB.CuiY

Elsevier Press

Heat from cooking, outdoor activities, steam, or hot showers can stimulate pigment cells, making freckles appear darker

The DIO3 gene codes for D3, which is detected in brain, skin, liver, intestine, placenta and pregnant uterus, where it catalyzes the inactivation of T4 and T3