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32 Efflux lowers the intracellular drug concentration below inhibitory levels

10.29252/jarums.18.2.215 67

Severe sarcopenia can also lead to impaired physical function, reduced activities of daily living, decreased exercise tolerance, and balance disorders, which increase the risk of fractures by 23 times (32, 3537)

A few key ones include: Selenium: Selenium is a known antioxidant and the right balance is essential to health

Moreover, ROS induced by copper and iron can cause DNA double-strand breaks, cell cycle arrest, mitochondrial dysfunction, lipid peroxidation and protein modification, which may ultimately mediate diverse types of cell death [29,30,31] (Table 1)