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If it is cloudy, contains particles that will not dissolve, or looks discolored, do not use it

Melanie Avalon Oh, it's a set one

Nardin P, Tortorelli L, Quincozes-Santos A et al (2009) S100B Secretion in acute brain slices: modulation by extracellular levels of Ca2+ and K+

An RCT can show that an intervention is responsible for an observed difference in outcomes, but it does not prove that a proposed mechanism of action is the reason the effect occurred