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Despite successful conception achieved through medication, surgery, or assisted reproductive technology, patients may face various challenges such as early pregnancy miscarriage, gestational diabetes mellitus (GDM), gestational hypertension, and preeclampsia

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Patients who receive metformin have improved long-term survival, suggesting advantages for HCC patients treated with metformin in combination with sorafenib [219]

Therefore, the clinician must have a low threshold to raise the issue of possible ALD, and has to rely on indirect evidence of alcohol abuse, such as questionnaires, information from family members, or laboratory tests to strengthen or confirm a clinical suspicion