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You cant overdose, and theres no toxicity threshold

151 ZhangS

We reminded readers that our evidentiary standard of demonstrated clinical benefit does not include minor or incidental benefits (81 FR 80194)

Individual MEFs (n = 3 total) are shown, separated into MEF (no doxycycline) and OSKM (72 h of doxycycline treatment to induce OSKM expression) conditions