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This happens as they are overworked, and as you age

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Simitsopoulou M, Roilides E, Georgiadou E, Paliogianni F, Walsh TJ (2011) Differential transcriptional profiles induced by amphotericin B formulations on human monocytes during response to hyphae of Aspergillus fumigatus

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This results in mitochondrial dysfunction, characterised by diminished Ca2+ flux, reduced mitochondrial ROS production, and intracellular acidosis, all contributing to the impairment of forward motility and fertility