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The activation of IER3 in the mucosa downregulates Nrf2 through the PI3K/Akt pathway, leading to decreased ROS production and apoptosis in a colitis model, which keeps Nrf2 levels low in IBD (94)

[DOI] [PubMed] [Google Scholar] 234.Khalil AS, Xie AW, Johnson HJ, Murphy WL

Biochemistry 1991;30(11):2817-22

Apply a moderate amount on a clean face after cleansing

The test was done at the end of the experiment (after the 2 weeks of the treatment) and repeated three times for each rat, and the average value was computed