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The M3R is also expressed on brain microvascular endothelium (Radu et al., 2017), and M3R signaling is also important in adaptive immunity and autoimmunity (indeed, M3R is a candidate receptor for autoantigen recognition by T and B cells) (Sumida et al., 2014)

Pro- and anti-inflammatory cytokines are the game-changers in childhood obesity-associated metabolic disorders (diabetes and non-alcoholic fatty liver diseases)