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In renal epithelial cells, TRPV4 channel activation results mainly from hypotonic cell swelling, which suggests that TRPV4 acts as an osmosensor and could play a critical role in renal ischemic/reperfusion injury 41,42 and in autosomal recessive polycystic kidney disease 43

Main text Antioxidants overview While this manuscript focuses on the effect of antioxidants as adjuvant therapy in patients with CAP, it is important to note that the available studies specifically addressing CAP are limited

The Folin Ciocalteu reagent [8] however cannot be carried out unless the concentration of Nycodenz or iodixanol is less than 5% (w/v): this situation however can often be attained if the final assay volume is 1-2 ml and the volume of gradient fraction used is 50 l

We accomplished sensitivity analysis to find the effect of each particular study on the overall estimation (Reference Tobias45)