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The reason for this is that NF-B of Cd38 KO mice was greatly weakened in a collagen-induced arthritis mouse (CIA) model ( Figure 1

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the inventors also surprisingly found inhibitory activity with certain embodiments of the invention where R 1 is methyl with dual positional substitutions (see e.g., compounds 2j, 2m, 2k, and 2l, Table 2)

It persuades the body to make more of its own, keeping the entire hormonal axis engaged and the testes functional