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The decreased macrophages (clusters 2, 4, 5, 7) suggested that FAPCAR-T cells disrupted the viscous inflammatory-fibrosis cycle via the clearance of overactivated fibroblasts, which was consistent with the flow cytometry and proteomics results

Poor technique can denature the peptide, create foam that wastes product, or introduce contamination that ruins the entire vial

Although it is unlikely that such uptake results in the propagation of infection, the delivery of the virus to endosomal compartments can trigger pattern-recognition receptors and induce inflammatory cascades

The same antibody was analyzed ex vivo using Myeloma Drug Sensitivity Testing to identify suitable MM patients for this therapy

36 In some situations, the specific risk factor may have been mitigated and is no longer a concern (e.g., a high triglyceride level that is now within normal range, previous excess alcohol use in a patient who is currently sober, history of gallstones since resolved by cholecystectomy)