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Mechanistically, -KG decreases Treg differentiation by inhibiting FOXP3 and upregulating inflammatory cytokines such as IFN-, Tbet, and Rorc, suggesting that Th1-type effector T cells are more dependent on glutaminolysis than Treg cells 136

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Others report mild decreases during the initial days of use

Mutant Profilin1 transgenic mice recapitulate cardinal features of motor neuron disease

CBD can directly influence various cell types, including neurons and immune cells, by targeting distinct molecular pathways, thereby modulating their functions