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This restoration leads to improved mitochondrial health, enhanced CCO activity, angiogenesis (via VEGF signaling), and attenuation of cardiac hypertrophy [35, 178]

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Zhe Yang, [email protected]

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Research suggests it plays a role in modulating the hypothalamus, influencing neurotransmitters such as GABA, serotonin, dopamine, and noradrenaline

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PMID: 29 CriscioneSWMartinMJOienDBGorthiAMiragaiaRJZhangJet al

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In the landmark 2017 study, FOXO4-DRI selectively induced apoptosis in senescent human fibroblasts (IMR90 cell line) while sparing non-senescent cells at an 11.73-fold selectivity ratio

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