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Werner syndrome is the most common accelerated-aging syndrome derived from DNA repair defects, caused by the mutations of Werner syndrome ATP-dependent helicase ( WRN ), a gene coding for a protein implicated in telomere maintenance and homology-dependent recombination repair (Osorio et al., 2011)

Moreover, One study conducted with 94 BD patients and 41 healthy controls reported higher OS index levels in the BD patients compared with the controls (Yumru et al., 2009)