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Compound 30 encompassing a homo tyrosine in a 14-membered macrocycle and with a trans double bond provided the lowest Ki value in the series, 1.8 nM, while the corresponding tyrosine analogues with the 13-membered ring system exhibited a Ki value of 50 nM

In adults, treatment length varies based on symptom relief and IGF-1 targets, and some may use it indefinitely if benefits persist (with periodic re-evaluation)

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