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Moreover, recombinant human IGF-1 replacement has been useful in reversing the adverse conditions associated with GH deficiency or GH insensitivity in children (10, 11)

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Plasmid constructs FLAG-UBR5 (#37188), HA-GSK3 (#14753), HA-GSK3-S9A (#14754), and HA-GSK3-K85A expression plasmids were from Addgene (USA)

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