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Sci Rep 11 , 6985 (2021)

Ursolic acid, a pentacyclic triterpene is another active component of Rosmarinus officinalis

Overall, this scalable pH shift strategy, particularly when using Bis-Tris as a pre-elution buffer and amino acids in the elution buffer, offers a viable approach for mitigating harsh low pH elution conditions, thereby enhancing protein stability and yield