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2 Materials and methods 2.1 Datasets The gene expression profiles of HepG2 cells were analyzed, comparing three untreated samples to three samples treated with INH (GSE168473, NCBI Gene Expression Omnibus, GEO)

These observations also highlight that therapeutic approaches should be directed at specific aspects of astrocyte reactivity, for example astrocyte Ccl2 production, rather than at attenuating reactivity per se, which may lead to unexpected and undesirable consequences

These findings indicate that NAC effectively ameliorates EAAC1 deficiency-induced neurogenic deficits by restoring DCX-expressing immature neurons and Ki67-positive proliferating cells in DG