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10.1096/fj.04-3485cmt [DOI] [PubMed] [Google Scholar] 121.Maines MD (1997) The heme oxygenase system: a regulator of second messenger gases

Together, these effects create a cascade of dysfunctions that exacerbate hypothyroidism symptoms and overall health decline (Reference Zegers-Delgado, Blanlot and Calderon15)

10.1042/AN20100033 [DOI] [PMC free article] [PubMed] [Google Scholar] 57.Hoffmann C, Dietrich M, Herrmann AK, Schacht T, Albrecht P, Methner A

Evidence for ligand-independent transcriptional activation of the human estrogen-related receptor alpha (ERRalpha): crystal structure of ERRalpha ligand binding domain in complex with peroxisome proliferator-activated receptor coactivator-1alpha

It can be improved within 1-2 weeks, whereas some chronic diseases, such as arthritis or tissue regeneration, can require 4-6 weeks or more