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Limited Treatment Options for Diabetic Wounds: Barriers to Clinical Translation Despite Therapeutic Success in Murine Models

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Jiang Chang: Data curation, Supervision, discussed the data

When GHK binds with a copper ion (Cu2+), it forms the copper peptide GHK-Cu, the bioactive complex responsible for its profound regenerative effects

Even when ingested in normal amounts, copper and iron may become toxic in certain individuals with genetic predispositions that lead to hepatic overload - iron overload in hemochromatosis [11-17] or copper overload in Wilson disease [18-27]